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Receptors of pathogens and hosts (Lisa Bäumer / Lisa Ott)

While different virulence factors of C. diphtheriae and the general adhesion process are well characterized, the receptors of bacteria on the surface of host cells are unknown.

The main project of my research is based on generating monoclonal antibodies specific against C. diphtheriae surface proteins to identify molecules that are involved in the interaction between bacteria and epithelial cells. 

Furthermore, by using macrophage cells with different genotypes, we try to identify the pathogen recognition receptors (PRRs) of phagocytic cells that play a role in the activation of macrophages and the processing of pathogenic Corynebacteria.